Yuri Bunimovich, MD, PhD

  • Associate Professor, Department of Dermatology

Education & Training

  • BSc, Biomedical Engineering, Cornell University, 2000
  • PhD, Chemistry and Chemical Engineering, California Institute of Technology, 2007
  • MD, University of California Los Angeles; Jacobs School of Medicine, SUNY, 2009
  • Post Doctoral Fellowship, NanoSystems Institute, Crump Institute for Molecular Imaging, University of California Los Angeles, 2012
  • Dermatology Residency, University of Pittsburgh, 2015

Research Interests

  • Neuro-immune regulation of cancer progression.
  • Re-engineering of anti-tumor immunity for the development and testing of novel cancer immunotherapies.
  • Pathogenesis of lipid redox dysregulation in the inflammatory and autoimmune disorders.
  • Role of ferroptosis in the neoplastic and inflammatory skin diseases.
  • Glial functions in cancer, inflammation, wound healing and neuropathy.

Publications


1. Shurin GV, Kruglov O, Ding F, Lin Y, Hao X, Keskinov AA, You Z, Lokshin AE, LaFramboise WA, Falo LD Jr, Shurin MR, Bunimovich YL. Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth. Cancer Research, 2019;79(10):2736-2747. PMID: 30914431.


2. Vats K, Kruglov O, Mizes A, Samovich SN, Amoscato, AA, Tyurin VA, Tyurina YY, Kagan VE, Bunimovich YL. Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure. Redox Biol. 2021 Nov;47:102143. PMID: 34592565.


3. Vats K, Kruglov O, Sahoo B, Soman V, Zhang J, Shurin GV, Chandran UR, Skums P, Shurin MR, Zelikovsky A, Storkus WJ, Bunimovich YL. Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses. Cancer Immunol Res. 2022;10(9):1141-1154. PMID: 35834791.


4.Tyurina YY, Karpalov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023;61:102650. PMID: 36870109.


5. Kruglov O, Vats K, Soman V, Tyurin VA, Tyurina YY, Wang J, Williams L, Zhang J, Donahue Carey C, Jaklitsch E, Chandran UR, Bayir H, Kagan VE, Bunimovich YL. Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production. Oncoimmunology 2023; 12(1):2192098. PMID: 3699820.