Lisa Borghesi, PhD
Contact
Ph: 412-383-7074
Fax: 412-383-8098
Education
- PhD, University of Connecticut
Academic Affiliation
Associate Professor, Department of Immunology
Scientific Director, United Flow Core
Executive Committee of the Faculty, Elected Member
Chair, AAI Advocacy Programs Subcommittee
Member, Graduate Program in Microbiology and Immunology (PMI)
About Research
Dr. Borghesi's research focuses on HSCs, the sole source of blood forming cells throughout life. It has long been known that infection triggers dramatic and rapid changes in hematopoietic output but the mechanisms remain murky. TLR4 is a dominant innate immune sensor for LPS and hence a model receptor for how the hematopoietic system adapts to pathogen exposure. Her laboratory is studying the mechanisms that enable stem cells to directly sense infection, and functionally respond with accelerated differentiation and/or lineage fate re-direction. Dr. Borghesi is an F1000 Faculty Member.
Selected Publications
Liu A, Chen M, Kumar R, Stefanovic-Racic M, O'Doherty R, Ding Y, Jahnen-Dechent W and Borghesi L. 2018. Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nat. Comm. 8: 708. PMID: 29453396
Liu A, Wang Y, Ding Y, Baez I, Payne K and Borghesi L. 2015. Hematopoietic stem cell expansion and common lymphoid progenitor depletion requires hematopoietic-derived, cell-autonomous TLR4 in a model of chronic endotoxin. J. Immunol. (Cutting-Edge). 195: 2524-2528. PMID: 26276875
Santos P, Ding Y and Borghesi L. 2014. Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells. J. Immunol. 192: 160-168. PMID: 24259504
Yang Q, Esplin B and Borghesi L. 2011. E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction. Blood. 117: 3529-3538. PMCID: 3072876
Martincic K, Alkan S, Cheatle A, Borghesi L and Milcarek C. 2009. Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nature Immunol. 10: 1102-1109. PMC2771556