Douglas K. Fischer

Douglas K. Fischer

Contact

451 Bridgeside Point II
450 Technology Drive
Pittsburgh, PA 15219

Ph: 412-383-9881

dkf12@pitt.edu

Education

  • MS in Computer Science, James Madison University, 2001
  • BA in Physics, Bridgewater College, 1995

Selected Publications

Ning J, Zhong Z, Fischer DK, Harris G, Watkins SC, Ambrose Z, Zhang P. 2018. Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid. J Virol. Jun 13;92(13)

Hendricks MR, Lashua LP, Fischer DK, Flitter BA, Eichinger KM, Durbin JE, Sarkar SN, Coyne CB, Empey KM and Bomberger JM. 2016. Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. Proc Natl Acad Sci USA. 113: 1642-1647.

Turner MS, Isse K, Fischer DK, Turnquist HR and Morel PA. 2014. Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes. Diabetologia. 57: 1428-1436.

Selected Abstracts:

Fischer DK, Watkins SC, Yamashita M, Ambrose Z. Distinct Capsid Uncoating and Host Cell Infectivity Phenotypes in HIV-1(NL4-3) and HIV-1(LAI) are Caused by Minor Sequence Differences in CA. Poster Presentation. (2017) NIH Structural Biology Related to HIV/AIDS Meeting. 29-30 June 2017. Bethesda, MD.

Fischer DK, Watkins SC, Yamashita M, Ambrose Z. Sequence Differences in CA of HIV-1(NL4-3) and HIV-1(LAI) Cause Distinct Capsid Uncoating and Host Cell Infectivity Phenotypes. Poster Presentation. (2017) Cold Spring Harbor Laboratory Retroviruses Conference. 22-27 May 2017. Cold Spring Harbor, NY.

Fischer DK, Watkins SC, Yamashita M, Polenova T, Ambrose Z. Minor Sequence Differences in HIV-1(NL4-3) and HIV-1(LAI) Capsid Cause Distinct Capsid Uncoating and Host Cell Infectivity Phenotypes. Poster Presentation. (2016) NIH Structural Biology Related to HIV/AIDS Meeting. 23-24 June 2016. Bethesda, MD.

Fischer DK, Zhong Z, Wallace C, Zhang P, Watkins SC, Yamashita M, Ambrose Z. Visualizing and Characterizing HIV-1 Capsid Uncoating in Infected Host Cells. Poster Presentation. (2015) Cold Spring Harbor Laboratory Retroviruses Conference. 18-23 May 2015. Cold Spring Harbor, NY.

D.K. Fischer, L.P. Lashua, K. McHugh, S. Manalapu, P.J. Dubin, J.F. Alcorn, J.M. Bomberger. Co-Infection with Respiratory Viruses Enhances Pseudomonas aeruginosa Biofilm Growth. North American Cystic Fibrosis Conference, 2012.

D.K. Fischer, L.P. Lashua, K. McHugh, S. Manalapu, P.J. Dubin, J.F. Alcorn, J.M. Bomberger. Co-Infection with Respiratory Viruses Enhances Pseudomonas aeruginosa Biofilm Growth. Pittsburgh International Lung Conference, 2012.

D. Fischer, L. Lashua, J. Bomberger. Respiratory Virus Co-Infection Enhances Pseudomonas aeruginosa Antibiotic Resistance and Biofilm Growth on Airway Epithelial Cells. Pittsburgh Bacterial Meeting, 2012.

Why did you choose the University of Pittsburgh?

The University of Pittsburgh has one of the strongest biomedical research programs in the country, and ranks highly in NIH funding. Pitt has a long history of innovations and breakthroughs in the biomedical sciences and is home to numerous noteworthy researchers. The cross-disciplinary and collaborative environment offers unique and exciting opportunities for work and education. All of this in a city voted one of the most livable in the country.

Research Interests

  • Host/Pathogen Interactions; Emerging Infectious Diseases; Biosecurity; Astrobiology, Synthetic Biology, and Extremophiles; Complex Adaptive Systems