Graham F. Hatfull, PhD
- Professor, Department of Biological Sciences, Dietrich School of Arts & Sciences
- Eberly Family Professor of Biotechnology
- HHMI Professor
Education & Training
- PhD, Department of Molecular Biology, Edinburgh University (UK), 1981
- BSc (Hons) in Biological Sciences, Westfield College, University of London (UK), 1978
Research Interests
Dr. Hatfull’s research focuses on the molecular genetics of the mycobacteria and their bacteriophages. These studies take advantage of the intimacy of phage-host interactions to gain insights into the genetics and physiology of Mycobacterium tuberculosis, the causative agent of human TB. Through integrated research-education programs such as the PHIRE and SEA-PHAGES programs, the large collection of completely sequenced mycobacteriophage genomes provides insights into viral diversity and evolution, and represents a rich toolbox of new approaches to understanding M. tuberculosis. Development of vector systems, selectable markers, recombineering approaches, expression tools, and insights into mycobacterial biofilms reflect some of the useful applications of this genomic resource.
Publications
Dedrick R, Guerrero Bustamante C, Garlena RA, Russell DA, Ford K, Harris K, Gilmour KC, Soothill J, Jacobs-Sera D, Schooley RT, Hatfull GF and Spencer H. 2019. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nat Med 25: 730-733.
Ko CC and Hatfull GF. 2018. Mycobacteriophage Fruitloop gp52 inactivates Wag31 (DivIVA) to prevent heterotypic superinfection. Mol Microbiol. doi:10.1111/mmi.13946.
Dedrick RM, Jacobs-Sera D, Guerrero Bustamante CA, Garlena RA, Mavrich TN, Pope WH, Reyes JC, Russell DA, Adair T, Alvey R, Bonilla JA, Bricker JS, Brown BR, Byrnes D, Cresawn SG, Davis WB, Dickson LA, Edgington NP, Findley AM, Golebiewska U, Grose JH, Hayes CF, Hughes LE, Hutchison KW, Isern S, Johnson AA, Kenna MA, Klyczek KK, Mageeney CM, Michael SF, Molloy SD, Montgomery MT, Neitzel J, Page ST, Pizzorno MC, Poxleitner MK, Rinehart CA, Robinson CJ, Rubin MR, Teyim JN, Vazquez E, Ware VC, Washington J and Hatfull GF. 2017. Prophage-mediated defence against viral attack and viral counter-defence. Nature Microbiol. 2: 16251. doi: 10.1038/nmicrobiol.2016.251.
Mavrich TN and Hatfull GF. 2017. Bacteriophage evolution differs by host, lifestyle and genome. Nature Microbiol. 2: 17112. doi: 10.1038/nmicrobiol.2017.112.
Hanauer DI, Graham MJ, Sea P, Betancur L, Bobrownicki A, Cresawn SG, Garlena RA, Jacobs-Sera D, Kaufmann N, Pope WH, Russell DA, Jacobs WR, Jr., Sivanathan V, Asai DJ and Hatfull GF. 2017. An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning. Proc Natl Acad Sci U S A. 114: 13531-13536.