Penelope A. Morel, MD

Our research is focused on the control of the T cell immune response and we are particularly interested in the factors that determine the differentiation of specific Th cell subsets, including T regulatory cells (Treg). This general area of research is being pursued in the several related projects. We have identified TCR signal strength as a major determinant of Th cell fate. TCR signals via the Akt/mTOR pathway play an important role in Treg differentiation. We have shown that RNA processing factors are differentially phosphorylated by Akt during Th and Treg differentiation. At present, we are examining the role of RNA processing factors in Treg differentiation using novel mutant mice that we have generated.  

We also use mathematical modeling to provide insight on how the TCR signaling pathway determines cell fate. This multidisciplinary project studies the important factors necessary to drive Treg and Th cell differentiation using a novel computer model. Predictions from the model are tested experimentally using T cells from TCR transgenic mice, analysis of signaling events and the tracking of immune responses in vivo.