Theresa L. Whiteside, PhD
- Professor, Department of Pathology
- Professor, Department of Immunology
- Professor, Department of Otolaryngology
Education & Training
- Post-Doctoral Researcher, NIH Special Fellow, New York University School of Medicine, 1967-1969
- PhD in Microbiology, Columbia University, 1967
- MA in Biology, Columbia University, 1964
- BS in Biology, Columbia University, 1962
Research Interests
Dr. Whiteside’s translational research has been focused on mechanisms of tumor-induced immunosuppression, cytokine networks, development of anticancer vaccines, immunobiology of human tumors and the role of natural immunity in the control of cancer progression. She studies mechanisms of tumor escape from the host immune system and the development of therapies designed to eliminate tumor escape in patients with HNC, melanoma, breast carcinoma and hematological malignancies. Most recently, she has been investigating tumor-derived exosomes (TEX) and their role in cancer-induced immune suppression.
Publications
Sharma P, Diergaarde B, Ferrone S, Kirkwood JM and Whiteside TL. 2020. Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells.” Sci Rep. 10: 92. doi: 10.1038/s41598-019-56542-4. PMID: 31919420
Ludwig N, Jackson EK, Whiteside TL. 2020. Role of exosome-associated adenosine in promoting angiogenesis. Vessel Plus. 4: DOI: 10.20517/2574-1209.2019.37
Czystowska-Kuzmicz M, 20 others, Whiteside TL, and Golab J. 2019. Small extracellular vesicles containing arginase 1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Comm. https://doi.org/10.1038/s41467-019-10979-3
Hong C-S, Jeong E, Boyiadzis M and Whiteside TL. 2020. Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in Acute Myeloid Leukemia. J Extracell Vesicles. 9: 1800979. PMID: 32944189. PMCID: PMC7480590 doi: 10.1080/20013078.2020.1800979.
Pietrowska M, Zebrowska A, Gawin M, Marczak L, Sharma P, Mondal S, Mika J, Polańska J, Ferrone S, Kirkwood JM, Widlak P and Whiteside TL. 2021. Proteomic profile of melanoma cell-derived small extracellular vesicles in patients' plasma: a potential correlate of melanoma progression. J Extracell Vesicles. 10: e12063. doi: 10.1002/jev2.12063. Epub 2021 Feb 11. PMID: 33613873 PMCID: PMC7876545