Heth R. Turnquist, PhD
- Associate Professor, Department of Surgery
- Associate Professor, Department of Immunology
Education & Training
- PhD in Pathology and Microbiology, University of Nebraska
- BS, South Dakota State University
Research Interests
The Turnquist lab works to decipher how immune cells interact with damaged tissue after injury caused by trauma and organ transplantation. We are particularly focused on gaining a better understanding of how “alarmins”, or typically sequestered self-derived immunomodulatory molecules regulate the immune system to orchestrate specific outcomes. The majority of our efforts use transgenic and knockout mice in pre-clinical models of solid organ and bone marrow transplantation, as well as tissue injury and systemic trauma. In collaborative efforts, we are also working to translate our basic discoveries into novel biologics and cell therapies used for the resolution of immune mediated pathology. Similarly, we are also working to identify effective biomarkers of disease states in transplantation.
Publications
Dziki JL, Velayutham M, Hussey GS, Ambrosio F and Turnquist HR. 2018. Cytokine networks in immune-mediated muscule regeneration. Journal of Immunology and Regenerative Medicine. In press.
Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, Xu L, Ramadan M, Brown J, Turnquist HR and Billiar TR. 2017. IL-33 mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. PLoS Medicine 14: e1002365.
Liew FY, Girard J-P and Turnquist HR. 2016. Interleukin-33 in health and disease. Nature Reviews Immunology 16 :676-689.
Mathews LR, Lott JM, Isse K, Lesniak A, Landsittel D, Demetris AJ, Sun Y, Mercer DF, Webber SA, Zeevi A, Fischer RT, Feingold B and Turnquist HR. 2016. Elevated ST2 distinguishes incidences of pediatric heart and small bowel transplant rejection. American Journal of Transplantation 16: 938-950.
Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MF, Liu Q, Zeiser R, Blazar BR and Turnquist HR. 2016. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood 128: 427-439.