Mark E. Snyder, MD
- Associate Professor, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
- Associate Professor, Department of Immunology
Education & Training
- Pulmonary and Critical Care Medicine Clinical Fellow, Columbia University, 2017
- Internal Medicine Resident, Columbia University, 2013
- MD, Stony Brook University School of Medicine, 2010
- BA, Economics, Cornell University, 2001
Research Interest Summary
Research Interests
The Snyder lab focuses on the role of tissue resident memory T cells in lung health and disease. Specifically, we focus on the maladaptive response of T cells leading to lung injury before and after transplantation leading to pulmonary fibrosis and chronic lung allograft dysfunction. To accomplishe these aims we emply a variety of approaches including systems immunology and experimental models.
Publications
Moghbeli K, Lipp MA, Bueno M, Craig A, Rojas M, Abbas M, Lakkis ZI, Chuan B, Sembrat J, Noda K, Kass DJ, Chen K, Fan L, Oury T, Zhou Z, Wang X, McDyer JF, Eickelberg O, Snyder ME. NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction. JCI Insight. 2025 Feb 24;10(4):e184048. doi: 10.1172/jci.insight.184048. PMID: 39989456; PMCID: PMC11949055.
Das A, Wang X, Devonshire K, Lyons EJ, Popescu I, Zhou Z, Li J, Sembrat J, Pilewski J, Zou C, Alder JK, Chen BB, Snyder ME, McDyer JF. IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance. J Immunol. 2024 Sep 15;213(6):898-905. doi: 10.4049/jimmunol.2400279. PMID: 39072690; PMCID: PMC12138907.
Snyder ME, Anderson MR, Benvenuto LJ, Sutton RM, Bondonese A, Koshy R, Burke R, Clifford S, Craig A, Iasella CJ, Hannan SJ, Popescu I, Zhang Y, Sanchez PG, Alder JK, McDyer JF. Impact of age and telomere length on circulating T cells and rejection risk after lung transplantation for idiopathic pulmonary fibrosis. J Heart Lung Transplant. 2023 Dec;42(12):1666-1677. doi: 10.1016/j.healun.2023.08.001. Epub 2023 Aug 5. PMID: 37544465; PMCID: PMC10839116.
Snyder ME, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, Tabib T, Lafyatis R, Chen K, Trejo Bittar HE, Lendermon E, Pilewski J, Johnson B, Kilaru S, Zhang Y, Sanchez PG, Alder JK, Sims PA, McDyer JF. Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. J Exp Med. 2022 Apr 4;219(4):e20212059. doi: 10.1084/jem.20212059. Epub 2022 Mar 14. PMID: 35285873; PMCID: PMC8924935.
Snyder ME, Finlayson MO, Connors TJ, Dogra P, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D'Ovidio F, Bacchetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL. Generation and persistence of human tissue-resident memory T cells in lung transplantation. Sci Immunol. 2019 Mar 8;4(33):eaav5581. doi: 10.1126/sciimmunol.aav5581. PMID: 30850393; PMCID: PMC6435356.