Mark E. Snyder, MD
- Assistant Professor, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
- Assistant Professor, Department of Immunology
Education & Training
- Pulmonary and Critical Care Medicine Clinical Fellow, Columbia University, 2017
- Internal Medicine Resident, Columbia University, 2013
- MD, Stony Brook University School of Medicine, 2010
- BA, Economics, Cornell University, 2001
Research Interests
The primary focus of Dr. Snyder's research is on the role of the adaptive immune system in the development of chronic rejection after lung transplantation. Chronic rejection is a progressive airway disease which remains a major limiting factor to long term survival following lung transplantation. Imbalances in the suppression of the adaptive immune system, leading to acute rejection or infection, have been implicated in the pathogenesis of chronic rejection.
Recently, Dr. Snyder identified that lung donor memory T cells, the predominant cell in the adaptive immune system, survive following transplantation and persist for weeks to months in the recipient. Furthermore, this survival of donor T cells is associated with improved short-term outcomes. Additionally, they found that lung allograft-infiltrating, recipient-derived T cells which migrate to the lungs following transplantation take up residency within the lung. His lab is focusing on determining the function and specificity of these tissue-resident memory T cells and if they are contributing to chronic rejection.
In addition to lung transplantation, the Snyder lab is actively investigating the role of tissue resident memory T cells on pulmonary fibrosis and chronic airway inflammation in human lungs.
Publications
Snyder ME, Sembrat J, Noda K, Myerburg MM, Craig A, Mitash N, Harano T, Furukawa M, Pilewski J, McDyer J, Rojas M, Sanchez P. Human Lung Resident Macrophages Co-localize with and Provide Co-stimulation to PD1hi Tissue Resident Memory T Cells. Am J Respir Crit Care Med. 2020 Dec 11. doi: 10.1164/rccm.202006-2403OC. Epub ahead of print. PMID: 33306940.
Szabo PA, Levitin HM, Miron M, Snyder ME, Senda T, Yuan J, Cheng YL, Bush EC, Dogra P, Thapa P, Farber DL, Sims PA: Single cell transcriptome profiling defines activation states and interrelatedness between human blood and tissue T cells. Nature communications, in press
Snyder ME, Finlayson MO, Connors TJ, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D’Ovidio F, Bacchaetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL: Generation and persistence of human tissue-resident memory T cells in lung transplantation. Sci Immunol 2019 Mar 8; 4(33): doi: 10.1126/sciimmunol.aav5581 PMID: 39850393, PMCID: PMC 6435356.
Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen Kleinhenz M, Kilaru S, Hays SR, Singer JP, Sanchez PG, Morrell MR, Pilewski JM, Greenland JR, Chen K, McDyer JF. Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction. Am J Transplant. 2020 Oct 20. doi: 10.1111/ajt.16360. Online ahead of print. PMID: 33078555
Senda T, Dogra P, Granot T, Furuhaushi K, Snyder ME, Carpenter DJ, Szabo PA, Thapa P, Miron M, Farber DL. Macroanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunol 2019 Mar;12(2): 378-389. doi: 10.1038/s41385-018-0110-8 PMID: 30523311, PMCID: PMC 6375790.