Patrick S. Moore, MD, MPH
- Distinguished Professor, Department of Microbiology & Molecular Genetics
- American Cancer Society Research Professor
Education & Training
- Postdoctoral and residency training: l’Hôpital Général Juif, McGill University, Montréal; US Centers for Disease Control, Atlanta.
- MPH in epidemiology, University of California, Berkeley & San Francisco
- MPhil in anatomy and cell biology, University of Utah
- MD, University of Utah
- MS in biophysical chemistry, Stanford University
- BS, Westminster College
Research Interests
Our laboratory used pioneering genomic techniques to discover two different cancer viruses (Kaposi sarcoma herpesvirus and Merkel cell polyomavirus) that are responsible for four different cancers. Our laboratory is jointly managed by Patrick Moore (MMG) and Yuan Chang (Pathology) in the Hillman Cancer Center. We use these viruses as tools to understand basic oncogenesis, which may have importance to both infectious and non-infectious cancers. Currently, we are studying the role of SCF E3 ligases in regulation of small DNA virus latency, we are investigating viral manipulation of cap-dependent protein translation in different phases of the cell cycle and we are exploring new techniques to find additional human cancer viruses.
Publications
Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM and Moore PS. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266: 1865-1869.
Chatterjee M, Osborne J, Bestetti G, Chang Y and Moore PS. 2002. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science. 298: 1432-1435.
Feng H, Shuda M, Chang Y and Moore PS. 2008. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100.
Kwun HJ, Chang Y and Moore PS. 2017. Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Proc Natl Acad Sci USA. 114: E4040-4047.
Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS and Chang Y. 2018. Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci USA. 115: E8737-8745.