Robin E. C. Lee, PhD
- Associate Professor, Department of Computational and Systems Biology
Education & Training
- PhD in Cellular and Molecular Medicine, University of Ottawa
We study the design of molecular circuits that regulate inflammatory signal transduction. To decide between irreversible cell fates such as growth, differentiation or death, cells process information about their environment through a network of molecular circuits. We enjoy using a variety of tools including CRISPR-mediated cell engineering, live-cell imaging, microfluidics, and computational modeling, to build an understanding of how cells encode and decode dynamic signals to transmit quantitative information. Our goal is to develop models with single-cell resolution to understand how heterogeneity between single-cells in the abundance of proteins affect their capabilities, and ultimately manipulate cell fate decisions in inflammation-associated diseases.
Wong VC, Bass VL, Bullock ME, Chavali AK, Lee REC, Mothes W, Gaudet S and Miller-Jensen K. 2018. NF-kappaB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise. Cell Rep. 22: 585-599.
Singh M, Warita K, Warita T, Faeder JR, Lee REC, Sant S and Oltvai ZN. 2018. Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. Sci Rep. 8: 9388.
Zhang Q, Gupta S, Schipper DL, Kowalczk GJ, Mancini AE, Faeder JR and Lee REC. 2017. NF-kappaB Synamicas Discriminate between TNF Doses in Single Cells. Cell Syst. 5: 638-645 e5.
Lee RE, Qasaimeh MA, Xia X, Juncker D and Gaudet S. 2016. NF-kappaB signalling and cell fate decisions in response to a short pulse of tumor necrosis factor. Sci Rep. 6: 39519.
Lee RE, Walker SR, Savery K, Frank DA and Gaudet S. 2014. Fold change of nuclear NF-kappaB determines TNF-induced transcription in single cells. Mol Cell. 53: 867-879.