Robin E. C. Lee, PhD
- Associate Professor, Department of Computational and Systems Biology
Education & Training
- University of Ottawa, Cellular and Molecular Medicine, 2009
- University of Ottawa, Physics-Mathematics
- Postdoc: Harvard Medical School Dept. of Genetics
Research Interests
We study the design of molecular circuits that regulate inflammatory signal transduction. To decide between irreversible cell fates such as growth, differentiation or death, cells process information about their environment through a network of molecular circuits. We enjoy using a variety of tools including CRISPR-mediated cell engineering, live-cell imaging, microfluidics, and computational modeling, to build an understanding of how cells encode and decode dynamic signals to transmit quantitative information. Our goal is to develop models with single-cell resolution to understand how heterogeneity between single-cells in the abundance of proteins affect their capabilities, and ultimately manipulate cell fate decisions in inflammation-associated diseases.
Publications
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics SW Smeal, CM Mokashi, AH Kim, PM Chiknas, REC Lee Nature Communications
A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB JA Cruz’, CS Mokashi’, GJ Kowalczyk, Y Guo, Q Zhang, S Gupta, DL Schippper, REC Lee Science Advances
A system for analog control of cell culture dynamics to reveal capabilities of signaling networks CS Mokashi, DL Schippper, MA Qasaimeh, REC Lee iScience
A network-centric approach to drugging TNF-induced NF-kB signaling NA Pabon, Q Zhang, JA Cruz, DL Schipper, CJ Camacho*, REC Lee* Nature Communications
NF-κB Dynamics Discriminate between TNF Doses in Single Cells Q Zhang, S Gupta, DL Schipper, GJ Kowalczyk, AE Mancini, JR Faeder, REC Lee Cell Systems