Larry P. Kane, PhD
- Professor, Department of Immunology
Education & Training
- Postdoc, University of California at San Francisco, 1996-2000
- PhD, University of California at San Diego, 1996
- BS, Boston College, 1988
Research Interests
Dr. Kane's lab is currently pursuing several projects:
1. The role of TIM-3 in T cells and mast cells
This project currently involves the study of - TIM-3, a novel protein of the T cell immunoglobulin and mucin domain family in regulation of T cell and mast cell function. Previous studies have suggested that TIM-3 has different effects on these two cell types, i.e. down-regulation of Th1 T cell function and upregulation of myeloid cell function. Among other things, they are interested in elucidating signaling pathways downstream of TIM-3 in these two cell types.
2. Regulation of T cell and mast cell activation by PIK3IP1/TrIP, a novel regulator of PI3K
Dr. Kane's lab has found that a novel transmembrane protein known as PIK3IP1 (PI3K-interacting protein 1) or TrIP (transmembrane inhibitor of PI3K) is expressed in both T cells and mast cells. This protein appears to restrict early activation of both cell types. The lab is currently characterizing mice with inducible deletion of TrIP to better understand how this protein functions in vivo.
3. Regulation of mTOR activation by Carma1 and MALT1
Dr. Kane and his lab recently elucidated a previously unappreciated connection between the proteins Carma1 and MALT1 and the mTOR pathway, the latter of which was thought to be controlled solely by a PI3K/Akt dependent mechanism. His lab is now working to further define this pathway and its consequences for T cell activation and differentiation.
Publications
Hernandez-Mir G, Raphael I, Revu S, Poholek CH, Avery L, Hawse WF, Kane LP, McGeachy MJ. (2019) The Alzheimer's Disease-Associated Protein BACE1 Modulates T Cell Activation and Th17 Function. J. Immunol. 203:665-675. PMID:31209103.
Nau N, Horzempa J, O'Dee D, Brown M, Russo B, Hernandez A, Dillon S, Chen J, Kane LP, Sanker S, Hukriede N. (2019) A predicted Francisella tularensis DXD-motif glycosyltransferase blocks immune activation. Virulence. 10:643-656. PMID:31314675.
Carroll K, Avery L, Treat B, Kane LP, Kinchington P, Hendricks R, St. Leger, A. (2019). Differential Expression of Immune Checkpoint Molecules on CD8+ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes. J Virology. In Press.
DeRiso EA, Szymczak-Workman AL, Montecalvo A, Murphy JM, Seminario M-C, Kane LP* and Bunnell SC* (2019) Polyubiquitin-dependent recruitment of NEMO/IKKγ into T cell receptor signaling microclusters. bioRxiv. doi: https://doi.org/10.1101/617126
Uche U, Szymczak-Workman AL, Grebinoski S, Piccirillo A, D’Cruz LM and Kane LP. (2018) PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J. Exp. Med. 215:3165-3179. PMC6279406.