Bill F. Hawse, PhD
- Assistant Professor, Department of Immunology
Education & Training
- PhD in Biophysical Chemistry, Johns Hopkins School of Medicine
- BS in Biochemistry, University of Notre Dame
T cells are mediators of the adaptive immune response. To properly mount a response, T cells use extracellular receptors to sense their environment and transduce signals to intracellular signaling networks. Following ligation of the T cell receptor (TCR) to an antigen, both phospholipid and kinase signaling networks are activated. Our working hypothesis is that T cells encode different signaling inputs by generating qualitatively different phosphoproteomes that drive alternate cellular differentiation programs. We are also interested in defining how phospholipid second messengers control T cell signaling. We utilize a combination of cellular immunology, mass spectrometry, biophysics, high resolution microscopy, high content imaging, chemical genetics and single cell assays to study the mechanisms underlying T cell activation. We utilize the mechanistic insight gained from signaling studies to rationally alter pathways to control T cell activation and differentiation in the context of multiple infection and autoimmune models. Current projects in the lab include: 1) identifying Molecular mechanisms that encode TCR signal strength, 2) defining mechanisms of cross-talk between TCR and cytokine signaling networks and 3) determining the proteomic differences that define memory T cell recall responses.
Cattley RT, Lee M, Boggess WC and Hawse WF. 2020. Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation. J Biol Chem. 295: 8236-8251.
Hawse WF, Cattley RT and Wendell SG. 2019. Cutting Edge: TCR Signal Strength Regulates Acetyl-CoA Metabolism via AKT. J Immunol. 203: 2771-2775.
Luo W, Hawse W, Conter L, Trivedi N, Weisel F, Wikenheiser D, Cattley RT and Shlomchik MJ. 2019. The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells. Nat Immunol. 20: 736-746.
Hawse WF and Cattley RT. 2019. T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols. J Biol Chem. 294: 4793-4805.
Piccirillo AR, Cattley RT, D'Cruz LM and Hawse WF. 2019. Histone acetyltransferase CBP is critical for conventional effector and memory T-cell differentiation in mice. J Biol Chem. 294: 2397-2406.