Nicole Scharping, PhD
Why did you choose the University of Pittsburgh?
I chose the University of Pittsburgh due to the cancer immunology faculty, the breadth of exciting basic and translational cancer immunology research, and the immunology department chair Mark Shlomchik.
After her successful thesis defense, Dr. Scharping accepted a position as a postdoc in the Goldrath Lab in the Biology Department at the University of California San Diego.
Immunometabolic requirements of T cell activation and exhaustion
Education & Training
- PhD in Microbiology and Immunology, University of Pittsburgh, 2019
- BS in Cellular, Molecular & Developmental Biology, University of Washington, 2011
Cancer Immunology; Immunometabolism; T cell biology
Ashley V. Menk, Nicole E. Scharping, Dayana B. Rivadeneira, Michael J. Calderon, McLane J. Watson, Deanna Dunstane, Simon C. Watkins, Greg M. Delgoffe. “4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses” Journal of Experimental Medicine, 2018.
Ashley V. Menk*, Nicole E. Scharping*, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, and Greg M. Delgoffe. “Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions” Cell Reports, 2018. *Co-first authors
Scharping NE, Menk AV, Whetstone RD, Zeng X and Delgoffe GM. 2017. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 5: 9-16.
Scharping NE and Delgoffe GM. 2016. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel). 4: pii: E46.
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL and Delgoffe GM. 2016. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 45: 701-703.
Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A and Rawlings DJ. 2016. Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation. J Immunol. 197: 4529-4534.
Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH and Rawlings DJ. 2016. B cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 213: 733-750.
Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ and Jackson SW. 2016. B cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Immunol. 196: 3525-3531.
Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ and Jackson SW. 2015. B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome. Eur J Immunol. 45: 2773-2779.