Paolo Dario Angelo Vignali, PhD

Why did you choose the University of Pittsburgh?

The strength and diversity of the Immunology department as well as the quality of medical training at UPMC.

Education & Training

  • PhD in Microbiology & Immunology, University of Pittsburgh School of Medicine, 2022
  • BA, University of Tennessee Knoxville, 2013

Research Interests

Cancer Immunology; Cellular Metabolism


Jayaprakash, P., Vignali, P. D. A., Delgoffe, G. M., & Curran, M. A. (2022). Hypoxia reduction sensitizes refractory cancers to immunotherapy. Annual Review of Medicine, 73, 251–265.

Scharping, N. E., Rivadeneira, D. B., Menk, A. V, Vignali, P. D. A., Ford, B. R., Rittenhouse, N. L., Peralta, R., Wang, Y., Wang, Y., DePeaux, K., Poholek, A. C., & Delgoffe, G. M. (2021). Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature Immunology, 22(2), 205–215. 

Watson, M., Vignali, P. D. A., Mullet, S., Overacre-Delgoffe, A., Peralta, R., Grebinoski, S., Menk, A., Rittenhouse, N., DePeaux, K., & Whetstone, R. (2020). 517 Regulatory T cell functional identity is sustained by a glucose: lactate axis that is exploited in the tumor microenvironment. Journal for ImmunoTherapy of Cancer, 8(Suppl 3), A317–A317.

Ni, X., Tao, J., Barbi, J., Chen, Q., Park, B. V, Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., Zheng, Y., Zhang, X., Wu, X., Vignali, P. D. A., Yang, C.P., Li, H., Pardoll, D., Lu, L., Pan, D., & Pan, F. (2018). YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity. Cancer Discovery, 8(8), 1026–1043.

Shen, Y., Vignali, P. D. A., & Wang, R. (2017). Rapid profiling cell cycle by flow cytometry using concurrent staining of DNA and mitotic markers. Bio-Protocol, 7(16), e2517–e2517.

Vignali, P. D. A., Barbi, J., & Pan, F. (2017). Metabolic regulation of T cell immunity. Immune Metabolism in Health and Tumor, 87–130.

Yang, H.Y., Barbi, J., Wu, C.Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J.H., Park, B. V, Bandara, S., & Novack, L. (2016). MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the Foxp3 transcription factor. Immunity, 45(1), 83–93.