Terence S. Dermody, MD
- Vira I. Heinz Professor and Chair, Department of Pediatrics
- Professor, Department of Microbiology and Molecular Genetics
- Member, Graduate Program in Microbiology and Immunology (PMI)
- Member, Integrative Systems Biology (ISB) Graduate Program
Education & Training
- MD, Columbia University, 1982
- BS in Biological Sciences, Cornell University, 1978
Our lab studies the molecular pathogenesis of mammalian reovirus infection. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, and disease is restricted to the very young. Reovirus is a promising oncolytic in combination therapy and can serve as a vector in vaccine development.
Research in my laboratory encompasses several interrelated themes to better understand viral and host mediators of reovirus replication and disease. These include the function of cellular receptors in viral attachment and tropism, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, and the role of different virus-induced cell death pathways and their significance in the viral life cycle.
Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM and Dermody TS. 2014. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 15: 681-691.
Doyle JD, Setencel-Baerenwald JE, Copeland CA, Rhoads JP, Brown JJ, Boyd KL, Atkinson JB and Dermody TS. 2015. Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. PLoS Pathog. 1: e1004693.
Bouziat R, Hinterleitner R, Brown JJ [...] Dermody TS and Jabri B. 2017. Reovirus infection breaks tolerance to dietary antigens and promotes development of celiac disease. Science. 356: 44-50.
Knowlton JJ, Fernández de Castro I, Ashbrook AW, Gestaut DR, Zamora PF, Bauer JA, Forrest JC, Frydman J, Risco C and Dermody TS. 2018. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat Micrbiol. 3: 481-493.