Louise D'Cruz, PhD
Ph: 412-383 5976
- Postdoc, University of California San Diego
- PhD, Institute of Molecular Pathology, Vienna, Austria
- BA, Trinity College Dublin, Ireland
Assistant Professor, Department of Immunology
Member, Graduate Program in Microbiology and Immunology (PMI)
The D’Cruz lab studies the interplay between adipose tissue and fatty acids and the cells of the immune system. With the catastrophic, growing global obesity epidemics, it is imperative that we understand how adipose tissue resident cells including effector T cells, NKT cells, ILCs and regulatory T cells play a critical role in affecting local and systemic inflammation. Under obese conditions these T cell populations are often perturbed, making them intriguing candidates for manipulation to prevent obesity-associated diseases including type II diabetes, certain cancers and cardiovascular disease. Specifically we study the transcriptional regulation of adipose resident T cells and are also exploring how transport of long chain fatty acids affects T cells responses in adipose tissue.
D’Cruz LM, Knell J, Fujimoto JK and Goldrath AW. 2010. An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and development of Natural Killer T cells. Nat Immunol. 11: 240-249.
Knell J, Best JA, Lind NA, Yang E, D’Cruz LM* and Goldrath AW.* 2013. Id2 influences differentiation of killer cell lectin-like receptor-like G1(hi) short-lived CD8+ effector T cells. J Immuno. 190: 1501-1509. *co-contributing authors
D’Cruz LM*, Stradner MH*, Yang CY and Goldrath AW. 2014. E and Id proteins influence invariant Natural Killer T cell sublineage differentiation and proliferation. J Immunol. 192: 2227-2236. *co-contributing authors
Stradner MH, Cheung KP, Lasorella A, Goldrath AW and D’Cruz LM. 2016. Id2 regulates hypo-responsive invariant Natural Killer T cells. Immunol Cell Biol. 94: 640-645.
Frias AB Jr, Buechel HM, Neupane A and D'Cruz LM. 2018. Invariant natural killer T-cell development and function with loss of microRNA-155. Immunol. 153: 238-245.