JoAnne L. Flynn, PhD

JoAnne L. Flynn, PhD

Contact

5058 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15261

Ph: 412-624-7743

joanne@pitt.edu

My Website »

Education

  • Postdoc, Albert Einstein College of Medicine, 1990-1993
  • Postdoc, Scripps Clinic, 1987-1990
  • PhD, University of California at Berkeley, 1987
  • BS, University of California at Davis, 1982

Academic Affiliation

Distinguished Professor, Department of Microbiology & Molecular Genetics

Distinguished Professor, Department of Medicine, Division of Infectious Disease

Distinguished Professor, Department of Immunology

Member, Center for Vaccine Research Member, Graduate Program in Microbiology and Immunology (PMI)

About Research

Dr. Flynn’s laboratory is focused on host-pathogen interactions and immunology of infectious disease. Specifically, her lab works on tuberculosis, a respiratory disease caused by the bacterium Mycobacterium tuberculosis. Tuberculosis is prevalent in most countries and kills 1.5 million people every year. Dr. Flynn studies the host response to tuberculosis and the pathogenesis of the disease, and works on treatments and preventive strategies, including vaccines. Her lab collaborates with many top research groups in the US and abroad, and develops and employs cutting edge technology to interrogate immune responses to M. tuberculosis.

Selected Publications

Gideon HP*, Hughes TK*, Tzouanas CN*, Wadsworth MH, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei J-R, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, White AG, Winchell CG, Nyquist SK, Ganchua SKC, Myers A, Patel KV, Ameel CL, Cochran CT, Ibrahim S, Tomko JA, Frye LJ, Rosenberg JM, Shih A, Chao M, Klein E, Scanga CA, Ordovas-Montanes J, Berger B, Mattila JT, Madansein R, Love JC, Lin PL, Leslie A, Behar SM, Bryson B, Flynn JL#, Fortune SM#, Shalek AK#. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity 2022 May 10;55(5):827-846.e10. doi: 10.1016/j.immuni.2022.04.004. Epub 2022 Apr 27.  *co-first authors; # co-senior authors

Grant NL, Maiello P, Klein E, Lin PL, Borish HJ, Tomko J, Frye LJ, White AG, Kirschner DE, Mattila JT, Flynn JL. T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Reports 39:7, p.110826, May 17, 2022. https://doi.org/10.1016/j.celrep.2022.110826. 

Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH, Hughes TK, Pokkali S, Swanson PA, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M*, Flynn JL*, Seder RA*. Prevention of tuberculosis in nonhuman primates following intravenous BCG immunization. Nature, 2020. Jan;577(7788):95-102. Epub 2020 Jan 1.  *co-senior authors

Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. PLoS Pathog. 2018 Oct 12;14(10):e1007305. doi: 10.1371/journal.ppat.1007305. eCollection 2018 Oct. 

Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov.0

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