Daniel Kaplan, MD, PhD
- MD/PhD, Washington University, St. Louis, MO
- Residency in Dermatology, Yale University School of Medicine
- Post-Doc, Yale University School of Medicine
Professor, Department of Dermatology
Professor, Department of Immunology
Member, Graduate Program in Microbiology and Immunology (PMI)
Member, Medical Scientist Training Program (MSTP)
Member, Physician Scientist Training Program (PSTP)
The skin is a barrier organ that is exposed to a wide variety of potential pathogens including bacteria, fungi and viruses. Within the skin there are numerous components of both the innate and adaptive immune system. The research focus of my lab is to understand how these skin resident immune cells (e.g. dendritic cells, T cells) interact with specific pathogens and other non-immune cells in the skin to contribute to the development of both innate and adaptive immune responses that provide host protection.
Kashem SW, Haniffa M, Kaplan DH. (2017). Antigen-Presenting Cells in the Skin. Annu Rev Immunol. 35: 469–499.
Kaplan DH. (2017). Ontogeny and function of murine epidermal Langerhans cells. Nat Immunol. 18: 1068–1075.
Mohammed J....Kaplan HD. (2016). Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β. Nature Immunology. 17: 414-421.
Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L and Kaplan DH. (2015). Nociceptive sensory fibers drive Interleukin-23 production from CD301b+ dermal Dendritic Cells and drive protective cutaneous immunity. Immunity. 43: 515-526.
Kashem SW, Igyarto BZ....Kaplan DH. (2015). Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation. Immunity. 42: 356–366.